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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EP300
All Species:
30
Human Site:
S1289
Identified Species:
55
UniProt:
Q09472
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q09472
NP_001420.2
2414
264161
S1289
T
R
K
E
N
K
F
S
A
K
R
L
P
S
T
Chimpanzee
Pan troglodytes
XP_515155
2411
263753
S1289
T
R
K
E
N
K
F
S
A
K
R
L
P
S
T
Rhesus Macaque
Macaca mulatta
XP_001102844
2414
264251
S1289
T
R
K
E
N
K
F
S
A
K
R
L
P
S
T
Dog
Lupus familis
XP_851777
2404
260682
S1290
T
R
K
E
N
K
F
S
A
K
R
L
Q
T
T
Cat
Felis silvestris
Mouse
Mus musculus
P45481
2441
265456
S1326
P
R
K
E
N
K
F
S
A
K
R
L
Q
T
T
Rat
Rattus norvegicus
XP_001076610
2413
263563
S1287
T
R
K
E
N
K
F
S
A
K
R
L
P
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_001233888
2444
267496
S1303
T
R
K
E
N
K
F
S
A
K
R
L
P
A
T
Frog
Xenopus laevis
NP_001088637
2428
264402
C1316
T
R
K
E
N
K
F
C
A
K
R
L
Q
T
T
Zebra Danio
Brachydanio rerio
XP_001332718
2667
289125
A1298
T
R
K
E
N
K
Y
A
A
K
R
L
P
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524642
3276
340709
N1947
K
R
K
E
N
K
F
N
A
K
R
L
P
T
T
Honey Bee
Apis mellifera
XP_001122031
2606
284119
N1526
K
R
K
E
N
K
F
N
A
K
R
L
P
V
T
Nematode Worm
Caenorhab. elegans
P34545
2056
227161
D1110
A
K
K
Y
Q
K
P
D
N
K
Y
L
A
S
K
Sea Urchin
Strong. purpuratus
XP_782558
2635
288594
T1534
K
K
K
E
N
K
F
T
A
K
K
L
Q
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
61
N.A.
58.6
94.1
N.A.
N.A.
85.1
60.4
57
N.A.
36.2
43
31.1
39.5
Protein Similarity:
100
99.7
99.5
72.4
N.A.
69.5
96.1
N.A.
N.A.
89.9
71
65.9
N.A.
46.6
54.9
45.6
51.5
P-Site Identity:
100
100
100
86.6
N.A.
80
100
N.A.
N.A.
93.3
80
80
N.A.
80
80
33.3
53.3
P-Site Similarity:
100
100
100
93.3
N.A.
86.6
100
N.A.
N.A.
100
86.6
93.3
N.A.
93.3
86.6
40
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
8
93
0
0
0
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
93
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
85
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
24
16
100
0
0
100
0
0
0
100
8
0
0
0
8
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
93
0
0
16
8
0
0
0
0
0
0
% N
% Pro:
8
0
0
0
0
0
8
0
0
0
0
0
62
8
0
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
31
8
0
% Q
% Arg:
0
85
0
0
0
0
0
0
0
0
85
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
54
0
0
0
0
0
39
8
% S
% Thr:
62
0
0
0
0
0
0
8
0
0
0
0
0
31
85
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _